Safi Bahcall received his BA in physics from Harvard and his PhD from Stanford. He co-founded Synta Pharmaceuticals—a biotechnology company developing new drugs for cancer.  He led its IPO and served as its CEO for 13 years. In 2008, he was named E&Y New England Biotechnology Entrepreneur of the Year. In 2011, he served on the President’s Council of Advisers on Science and Technology. Safi is the author of Loonshots: How to Nurture the Crazy Ideas That Win Wars, Cure Diseases, and Transform Industries. The book was selected by Malcolm Gladwell, Dan Pink, Susan Cain, and Adam Grant for the Next Big Idea Club.

 

Some interesting insights from this episode:

  • “Very often people go on a path that the world expects them to without ever pausing to say ‘why am I doing this?’”
  • For an entrepreneur, the critical ingredient for success in building a company is surrounding yourself with talented executives and then bridging the divide between people who wouldn’t naturally interact with one another.
  • Culture are the patterns of behavior you see on the surface in an organization while structure is what’s underneath that’s driving those patterns of behavior. The activities being rewarded (i.e. incentive structures) will drive the culture.  So it’s the structure that’s ultimately most important in influencing behavior.
  • As companies mature, employees tend to shift from focusing on collective goals toward focusing more on careers and promotions. To reduce that behavioral shift, you want to minimize the growth in compensation that comes with each level in the organization.  In addition, you want to maximize span of control.  With fewer promotions and less of a financial incentive as you move up the organization, employees will focus more on their projects and less on corporate politics.
  • You want some employees focused on activities that reduce risk and another set of employees focused on maximizing intelligent risk taking. Effective leaders create a dynamic equilibrium between these two groups and are able to effectively balance the core with the new.
  • Most innovative products will have at least one or two false fails on their way to achieving significant market traction. The key to success is to get really good at investigating failure and not just accepting it on face value.
  • Companies need to create a new C-suite role called a Chief Incentives Officer whose job is to design customized incentive packages to motivate employees and optimize outcomes.
  • “Excellence is always striving to improve yourself and improve your performance.”

Cindy Eckert is an entrepreneur who built and sold two pharmaceutical companies, notably Sprout Pharmaceuticals, creator of “female Viagra,” for more than $1B. She subsequently founded The Pink Ceiling which invests in companies founded by, or delivering products for, women.

 

Some interesting insights from this episode:

  • Moving every year during her childhood taught her how to be comfortable being uncomfortable. This experience of constant change would lay the foundation for the rest of her life.
  • While she had been surrounded by incredibly smart and hard working people in prior companies, she knew in her heart they weren’t any smarter or harder working than she was, so why not take a chance on herself.
  • She initially got turned down by the FDA for her drug for female low libido but rather that accept the verdict, she had the guts to challenge the FDA which eventually led to a reversal of their decision and approval for the drug.
  • After just four short years from the time she first purchased the drug, following the FDA approval, she sold the company for a billion dollars.
  • Culture is very important. Her company is the land of the misfit toys and they actually hire for quirkiness.  There is permission to bring your entire self to work and to be respectfully irreverent.
  • She tries not to get too obsessed with where things will lead. She’s just focused every day on getting up and doing a great job and creating value.
  • “I fail every day. Failure is just part of the test of how committed you are to the venture.”
  • “Empathy is the female DNA of a rule breaker.”
  • “Success isn’t about having all the answers. It’s about having the courage. If you feel you need to have all the answers, you’ll never succeed at entrepreneurship.”
  • “Why do we treat our career like a ladder? Why can’t it be a jungle gym?”

Dave Perkins is the Founder and former CEO of High West Distillery, a craft whiskey producer.  He sold the company in 2016 after 12 years to Constellation Brands for $160 million.  He had a successful career in biotech marketing prior to that.  He lives in Park City, Utah.

 

Some interesting insights from this episode:

 

  • Learn how his biotech background prepared him for building a whiskey business from scratch.
  • He moved to Utah to start the company despite the state’s tight liquor laws.
  • He chose to become a distiller, not just a blender, despite the much larger investment and longer waiting period.
  • Learn how good contingency planning can help mitigate risk in a startup.
  • In addition to hard work, good planning and a distinctive product, serendipity played a key role in his success.
  • Excellence is taking pride in your work and giving it your best.